Speaking about research is like talking about cooking. In cooking the cookbooks are helpful for prepare appetizing dishes after with a careful selection of ingredients and timing, not least the search should be based on sound science and follow guidelines known for some time. Just as it is better not to cook eggs in the microwave, in research it is better to avoid making blunders as evaluate the effectiveness of a drug / treatment using a drawing inappropriate. Continuing the similarities between the kitchen and the search is possible to think in drafting the protocol as the practical act of preparation. Many protocol are badly prepared! The main weaknesses identified in the protocols are summarized as follows: Tetzlaff JM, Chan A-W, Kitchen J, Sampson M, Tricco A, Moher D. Guidelines for randomized clinical trial protocol content: a systematic review. Syst Rev. 2012; 1:43. ...